Molecular Pharmacology Prostaglandin E receptor EP1 forms a complex with dopamine D1 receptor, and directs D1-induced cAMP production to adenylyl cyclase 7 through mobilizing G
نویسندگان
چکیده
Aliza T. Ehrlich, Tomoyuki Furuyashiki, Shiho Kitaoka, Akira Kakizuka, Shuh Narumiya Medical Innovation Center (A.T.E., T.F., S.K., S.N.) and Innovation Center for Immunoregulation Technologies and Drugs (S.N.), Kyoto University Graduate School of Medicine, Kyoto, Japan CREST, JST, Tokyo, Japan (A.T.E., T.F., S.K., S.N.) Laboratory of Functional Biology, Kyoto University Graduate School of Biostudies, Kyoto, Japan (A.T.E., A.K.) Molecular Pharmacology Fast Forward. Published on July 10, 2013 as doi:10.1124/mol.113.087288
منابع مشابه
Prostaglandin E Receptor EP1 Forms a Complex with Dopamine D1 Receptor and Directs D1-Induced cAMP Production to Adenylyl Cyclase 7 through Mobilizing Gbg Subunits in Human Embryonic Kidney 293T Cells
The mechanism underlying the crosstalk between multiple G protein–coupled receptors remains poorly understood. We previously reported that prostaglandin E receptor EP1 facilitates dopamine D1 receptor signaling in striatal slices and promotes behavioral responses induced by D1 receptor agonists. Here, using human embryonic kidney (HEK)-293T cells expressing D1 and EP1, we have analyzed the mech...
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